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Why the 3rd generation Arginine supplement is superior to all other formulas and what it can do for your lifespan

By Rainer Boger, M.D.


The Nitric Oxide machinery in our blood vessels becomes worn out with advancing age

Our blood vessel system is a fabulous system of tubes transporting blood from the heart into the organs and tissues (via the arteries), and back from there to the lung and the heart (via the veins). The heart muscle functions like a pump, keeping blood flow alive 24 hours a day, 7 days a week, and the lungs serve to refresh the oxygen content of the blood. With 70 heart beats per minute, it delivers 100,800 beats per day or 36.8 million beats per year. When we sleep, the heart does not rest, and when we exercise or get angry, the heart is pushed to maximal power by all the adrenaline in our system.

At the age of 55, our heart has performed more than 2 billion heartbeats without ever stopping. In order to adjust blood flow to all the various situations that we encounter in our lives, the arteries are not stiff (like water tubes made of copper or steel are stiff) – no, the arteries are flexible and adjust their inner diameter according to the need of blood flow for the respective organ or tissue that they bring the blood to. This is one of the biggest wonders of cardiovascular biology! For example, when we exercise on a bicycle, our leg muscles need lots of oxygen and nutrients to perform the exercise which are brought to the leg muscles through the blood stream. The arteries in the legs sense the higher need for oxygen and nutrients, and they increase their inner diameter so that even more blood can flow to the muscles!

How does this happen? In the arteries, the inner cell lining (which is called the “endothelium”) produces a tiny molecule, nitric oxide (NO). When endothelial cells sense the need for more oxygen and nutrients, they release NO, which relaxes the smooth muscle layer surrounding the artery, and the artery dilates (i.e., the inner diameter becomes wider and more blood can flow through).

At the time when we are born, the “NO machinery” works perfectly well, comparable to a brand-new sports car. Over time as we grow older, however, this machinery ages too. It becomes worn out and slows down its maximum performance; and in some people it starts to “stutter.” Why does this happen? Compare your body with the sports car that you once bought 55 years ago. Does the sports car still run at the same pace as when it was brand new? No, it doesn’t. The engine is old, and there is rust and tiny defects all over which reduce its performance. The same is true for our body. There may be high blood pressure, you may have smoked for years, your cholesterol may be higher than your doctor wants it to be.… Each observation may not be severe taken by itself, but together they add up to cause some severe malfunction of your cardiovascular system – even if you cannot feel any symptoms of it (as yet).

The way the NO machinery functions – or not

Nitric oxide is produced in the endothelial cells of our arteries from the amino acid L-arginine. Being an amino acid, L-arginine is a building block of proteins, and with the proteins that we eat, we consume about 5 – 6 g of L-arginine each day. An enzyme named nitric oxide synthase in the endothelial cells takes up L-arginine and converts it into NO. NO then moves to the muscle cells surrounding the arteries and causes them to relax – the artery widens. On its way from the endothelial cell to the muscle cell, NO can be attacked by superoxide radicals. Superoxide radicals are toxic oxygen radicals that are formed when inflammation is present; these oxygen radicals react with NO and inactivate it.

There are multiple mechanisms by which the biological functions of NO may be diminished

First, we need to have enough enzyme – Nitric Oxide synthase – in our endothelial cells. The Nitric Oxide synthase is like the engine of your sports car – when there is not enough enzyme within the cells, the system cannot work like a brand new Porsche car, but rather like – let’s say – an old Tin Lizzy.

Second, this NO engine needs to have enough of the right fuel – racing car fuel, not gasoline – to go full power. For the Nitric Oxide synthase, L-arginine is the fuel from which it forms NO. Many people develop a deficiency in L-arginine during the course of their life. This may be due to malnutrition (fast food, high fat, high carbohydrates …) and high levels of ADMA, an inhibitor of NO synthase, which may also cause relative L-arginine deficiency. Many people with cardiovascular risk factors like high blood pressure, high blood cholesterol, diabetes, and other conditions are known to have high ADMA levels.

Third and last, reactive oxygen species are produced when the vascular wall is not healthy. Oxygen radicals react with Nitric Oxide, leading to a loss of function of Nitric Oxide and to the production of peroxynitrite, a toxic reagent that destroys tissues and cells – this situation is known (and dreaded) as “nitrosative stress”.


The benefits of arginine and why there have been limitations of L-arginine supplementation

A vast number of experimental studies suggest that supplementation with L-arginine improves vascular function and protects from high blood pressure, atherosclerosis, and vascular disease in animals. In all of these studies, however, the experimental animals received L-arginine in their drinking water at their continuous disposition. It has been known for 20 years that in humans, L- arginine has a very short duration of action; L-arginine remains in the blood for only about one hour (this is called the “half-life”). With such a short half-life, L-arginine needs to be ingested every 2 – 3 hours in order to keep its blood levels high throughout the day – impossible to do for anybody in the long run.

Despite this knowledge, many clinical studies in human subjects have used L-arginine as is for twice daily administration. No wonder that the results were very variable and controversial. For example, in one large, NIH-funded study, patients who had experienced an acute myocardial infarction were treated with L-arginine or placebo. The study was stopped when no benefit was observed but with a higher mortality in the L-arginine group. In the publication of their results, the authors had to admit that L-arginine blood levels were lower in the L-arginine-treated group than in the placebo group. No wonder, an expert would say, because twice daily administration means 12 hours in between doses; during this time L-arginine blood levels will fall back to baseline for at least two thirds of the time. In another study, L-arginine did not improve walking distance in patients with an arterial occlusion in the leg artery. Again, the authors of the study reported twice daily administration of pure L-arginine, and they showed that most of the L-arginine was converted by arginase, not by NO synthase. Many other studies have found that L-arginine does improve exercise tolerance, reduces blood pressure, and normalizes “endothelial function”. In 2011, a meta-analysis (this is a kind of statistical analysis that extracts the data from multiple published studies to generate a reliable view on the efficacy of a medical treatment) clearly showed that L-arginine supplementation reduces systolic blood pressure (the upper blood pressure value) and diastolic blood pressure (the lower value) by about as much as low-to-medium doses of registered, pharmaceutical blood pressure lowering drugs do.

Several groups of researchers have reported in the recent years that L-citrulline – which is another amino acid that is naturally present in our food – is readily absorbed in our intestines and is thereafter converted into L-arginine. This process takes some time, so it is no wonder to see that L-arginine blood levels remain elevated for a longer time after an oral dose of L-citrulline than after an oral dose of L-arginine. Too much of L-citrulline is no good either, so the combination of an optimized ratio of L-arginine to L-citrulline in the dietary supplement was found to be ideal for keeping L- arginine blood levels up long enough to allow for twice daily ingestion of the supplement.

However, when studying the market of dietary L-arginine supplements, the vast majority of products still contain just L-arginine – no matter whether this works or not. Just very few products contain the combination of L-arginine and L-citrulline, and even fewer contain the optimal ratio of 3:1. It is important that people learn that this is a crucial point for spending their money for a product that works rather than for a product that helps no one but the manufacturer.


The outstanding benefits of the 3rd generation formula – Arginine Advantage Complete

Even the combination of L-arginine plus L-citrulline can improve just one out of three pathological conditions in the NO machinery (see above). It is the right fuel for the enzyme, the racing fuel. The two other defects remain unchanged with L-arginine plus L-citrulline. However, the 3rd generation formula of Arginine Advantage Complete has been formulated based on scientific data to tackle all three problems: Arginine Advantage Complete contains a proprietary blend of herbal extracts that have been shown scientifically to increase the levels of the NO synthase enzyme. Using the image of the sports car, this is like exchanging the Tin Lizzy’s old engine with a new Porsche engine. Only now can the race fuel – the L- arginine plus L-citrulline – delivers its full potential.

Nevertheless, the Arginine Advantage Complete formula can do more: The proprietary blend of herbal extracts was designed to diminish toxic oxygen radials, and scientific data have shown that it does so.

Arginine Advantage Complete puts the cells into a position to fight against toxic oxygen radicals coming from the outside, e.g. from inflammatory cells. The formula also blocks the de novo formation of oxygen radicals in the endothelial cells, and by this means it has a dual action against oxidative stress from inside and from outside of the cell.


Just recently Arginine Advantage Complete has been upgraded and improved to extract calcified plaque out of the vessels and heart. Before this improvement it only took out the cholesterol plaque. We have done this with 300 mcgs of Vitamin K2 in the form of MK7. Also, to enhance the effectiveness we added 800 IUs of vitamin D3. This addition will challenge stents and open-heart surgeries based on the latest US federal study just completed, where medication was just as effective. We are in a double-blind study started in October, 2019. Arginine Advantage Complete will challenge the current medical protocol. 


In the just-published book Lifespan by Dr. David Sinclair PhD, professor of genetics at Harvard Medical School, who has received over 35 awards for his research and is considered one of the top 100 influential people in the world, he says that aging is a disease and that disease is treatable; there is no gene that causes us to age - just our lifestyle. We should be able to live way beyond our current lifespan. He has established through research with dozens of researcher/associates over 30 years that there are 9 things we can do to increase our lifespan substantially and stay out of the disease phase of life. He states that if we can just affect one of the nine reasons, we will live substantially longer and healthier. Arginine Advantage Complete will affect and treat at least three of the nine reasons we age. (cardiovascular disease treatment by Nitric Oxide and reduction of inflammation, lengthen telomeres in our cells, and repair and increase mitochondria in our cells). It turns out that Resveratrol extends life substantially in lab tests on animals by 25%. It has been proven to increase mitochondria, reduce inflammation, and lower blood sugar. Resveratrol protects against dozens of diseases including cancer, stroke, heart attacks, inflammatory diseases and makes us much healthier. Most arginine products use red wine extract instead of Resveratrol because it is much cheaper but ineffective in all these health benefits. Arginine Advantage Complete only uses the highest quality ingredients. I will keep you posted on the other 6 reasons.


  The cause of cardiovascular disease after 35 years of research


After 35 years of research at the Cleveland clinic, Dr. Caldwell Esselstyn established that the lack of Nitric Oxide was the cause of cardiovascular disease. Arginine Advantage Complete is the strongest producer of Nitric Oxide in the industry of arginine production by the endothelium to Nitric Oxide by more than 800%. The vessels are the only way that the body can distribute Nitric Oxide throughout the body. This is the strongest and most important of the 9 lifespan processes. You see, not only do you want to live longer, you also want to live in the health phase of life, not the disease phase of life. That is what Arginine Arginine Advantage Complete can do for you. 


   And finally, Arginine Advantage Complete contains high quality L-arginine plus L-citrulline in the optimal dose 

   ratio of 2:1. Thus, this supplement is the only one on the market worldwide which addresses all 

   three problems that may lead to nitric oxide deficiency – it is the Porsche amongst the L-arginine

   supplements! I do not know how to say it more succinctly than that!!


Rainer Boger, MD and Professor of Medicine

University of Hamburg, Germany

28 years of research on cardiovascular disease and arginine

"Doctors today don't have the answer to reversing or curing high blood pressure."

Have you heard your doctor say, "there's no cure for high blood pressure". Yes? We know you probably have.

And, sadly, there's a common cycle many medical related products go through. It generally takes 20 years for a breakthrough remedy, to finally become mainstream, accepted medicine. The fact is, now 18 years later, doctors are still stating that there's "no cure or treatment" for high blood pressure. Recently the National Institute of Health (NIH) has come out with an announcement that L-Arginine helps Nitric Oxide production.

See here: https://www.nlm.nih.gov

"L-Arginine & L-Citrulline in proper ratio's are one of the best possible solutions for increased Nitric Oxide production."

L-Arginine/L-Citrulline is used by the Endothelium in the blood vessel to produce Nitric Oxide, which relaxes the blood vessels. This reduces stress on the heart and also improves blood circulation. L-Arginine/L-Citrulline is the body's only sources for Nitric Oxide synthesis. L-Arginine/L-Citrulline also reduces blood viscosity. It has been known to relieve Angina. When you reverse Atherosclerosis (which is a cleaning out of the arteries) and Arteriosclerosis (Making the vessels flexible again) you could have normal blood pressure again. L-Arginine/L-Citrulline are known ingredients to help low Nitric Oxide production.*** It took over 27 years of scientific experimenting by leading scientist to optimize the mixture of ingredients.


Taking L-arginine by itself could take years to accomplish what ARGININE ADVANTAGE® should do in less than 1 year.* The Nobel Prize for medicine in 1998 was all about L-Arginine being turned into Nitric Oxide by the Endothelium. This signaling molecule repairs the vessels and causes the blood to flow more normally.****


Blood pressure is the force in the arteries when the heart beats (Systolic Pressure) and when the heart is at rest (Diastolic Pressure). High blood pressure (Hypertension) is defined in an adult as a blood pressure greater than or equal to 140 mmHg systolic pressure or greater than or equal to 90mm Hg Diastolic Pressure. You should have readings below 120 over 80. Even if your blood pressure is in the "high normal" range you are at increased risk for medical problems associated with hypertension.

More people visit their doctor's office for Hypertension (High Blood Pressure) than for any other reason. In fact, a startling 50 million Americans have high blood pressure. About 32 percent of the people with hypertension are not even aware that they have it, and another 26 percent are taking blood pressure-lowering medications, all of which have side effects as they still face hypertension. Normally you don't feel high blood pressure until its abnormally high, and this absence of physical symptoms makes hypertension particularly dangerous. Unless you have your blood pressure measured, you will not know whether it is high. Though hypertension does not produce outward signs, high blood pressure still might be causing major internal damage by injuring the Endothelium thereby impairing the body's ability to produce its own Nitric Oxide (NO). This scenario gradually leads to inflammation of the arteries, which is followed by Atherosclerosis and plaque formation. Hypertension can also enlarge the heart, trigger a heart attack or stroke, and set the stage for a kidney failure.

If you have Hypertension, like 50 million American men & women, you run seven times the risk of having a stroke compared to individuals whose blood pressure is normal.

Why blood pressure soars in the first place.

To understand high blood pressure, picture a garden hose with a nozzle on its tip. There are two ways to increase the water pressure. Either you can open the faucet and pump more water through the hose, or you can tighten the nozzle and increase the resistance to the out flow of water. Blood pressure works in exactly the same way, depending on the amount of blood being pumped by the heart and the resistance of the flow of blood. The resistance to blood flow is a function of the width of the arteries, a characteristic that works in the same way the nozzle on the garden hose can constrict and dilate. Arteries that are constricted restrict the flow of blood while increasing the blood pressure. Conversely, if arteries are relaxed and widened, blood flows more easily and blood pressure decreases. ARGININE ADVANTAGE® was designed to replenish Nitric Oxide and thereby restore the body's ability to widen the arteries.*

Why we all must age proof our cardiovascular system? The famous Framingham heart study followed several generations of residents in the town of Framingham, Massachusetts, over 30 years, taking detailed cardiovascular health assessments on each person every two years. One of the more intriguing findings was that two thirds of the participants who started out with normal blood pressure in their thirties had developed hypertension as they aged. According to the National Institute of Health, hypertension plays a role in approximately 700,000 deaths per year. If you are building Nitric Oxide 24 hours a day every day you are doing a lot to help yourself against these numbers. See here: http://www.mayoclinic.org/


*Results May Vary | These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.