about | the science behind nitric oxide
What Nitric Oxide (NO) does for the Health
of your Cardiovascular System
In 1998 Dr. Louis Ignarro B.S., Ph.D. (author of NO More Heart Disease) and 2 other researchers were awarded the Nobel Prize for medicine. They had discovered that the endothelium produces Nitric Oxide from arginine and that the Nitric Oxide is a signaling molecule which travels throughout the blood vessels repairing the endothelium and helping the vessels become more flexible.
Nitric Oxide is an Endogenous Protector of the Vessel Wall
1 | Vasodilation
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2
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6 | LDL Oxidation
5 | Superoxide Radical Elaboration
3 | Monocyte Adhesion
2 | Platelet Aggregati
4 | Smooth Muscle Cell Proliferation
Nitric Oxide (NO)- is an Endogenous (produced by cells inside the organism such as the Endothelium) Protector of the Vessel Wall. Nitric Oxide is produced by the Endothelium (inner wall of all your vessels) as a protector of the vessel walls. Nitric Oxide also is responsible to repair the problems of the vessels, which includes returning them to a supple state.
1 | Vasodilation
Nitric Oxide increases the area of the vessel and as such increases the flow of blood to the crucial organs.
2 | Platelet Aggregation
Nitric Oxide breaks up the aggregation (accumulation of blood platelets) and thereby keeps the vessel clean.
3 | Monocyte Adhesion
Nitric Oxide prevents monocyte adhesion. The monocyte is created in the bone marrow and enters the blood and migrates into connective tissue where it forms into a acrophage to cause inflammation. Thus, inflammation pushes the blood vessels to get worse with time-nitric oxide blocks inflammation by inhibiting monocyte adhesion and thereby stops the progression.
4 | Smooth Muscle Cell Proliferation
Nitric Oxide blocks smooth muscle cell proliferation (growth). Proliferation of these cells makes the artery get narrower, so that less blood can flow to the organs. By reducing this mechanism, nitric oxide helps keep the arteries wide open.
5 | Superoxide Radical Elaboration
Nitric Oxide protects against this process of damage to the body. Superoxide radicals contribute to the development of many diseases and to the aging process because of oxidative stress, which damages cells and organ function.
6 | LDL Oxidation
Nitric Oxide reduces the oxidation of the bad cholesterol. Oxidation otherwise makes the bad cholesterol get even more aggressive in the blood vessels.
Asymmetric Dimethylarginine
(ADMA)
The science of the ADMA molecule & what the ADMA molecule can tell you:
HIGH BLOOD PRESSURE
SMOKING
CHOLESTEROL
HIGH CRP
INFLAMMATION
DIABETES
ADMA
Asymmetrical Dimethylarginine :
The Über Marker? (ADMA)
John P. Cooke
Online Version | Click Here |
Download .PDF
VASCULAR
DYSFUNCTION
HEART DISEASE
& DEATH
These Health & Lifestyle Markers
Effect the Vascular System
1 | Smoking
2 | Cholesterol
3 | Diabetes
4 | High Blood Pressure
5 | High CRP (C-reactive protein)
Is used mainly as a marker of inflammation. Apart from liver failure, there are few known factors that interfere with CRP production.[2] Measuring and charting CRP values can prove useful in determining disease progress or the effectiveness of treatments.
6 | LDL Oxidation
Nitric Oxide reduces the oxidation of the bad cholesterol. Oxidation otherwise makes the bad cholesterol get even more aggressive in the blood vessels.
The ADMA molecule is negatively affected by these 6 issues. Heart Disease and death follow if the ADMA is not attended to. The only real solution is an arginine/citrulline supplement. Your life style choices can change the ADMA in only a small amount.