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What Nitric Oxide (NO) does for the Health

of your Cardiovascular System

In 1998 Dr. Louis Ignarro B.S., Ph.D. (author of NO More Heart Disease) and 2 other researchers were awarded the Nobel Prize for medicine. They had discovered that the endothelium produces Nitric Oxide from arginine and that the Nitric Oxide is a signaling molecule which travels throughout the blood vessels repairing the endothelium and helping the vessels become more flexible.

Nitric Oxide is an Endogenous Protector of the Vessel Wall

1 | Vasodilation

Nitric Oxide Endogenous Protector of the Vessel Wall




6 | LDL Oxidation

5 | Superoxide Radical Elaboration

3 | Monocyte Adhesion

2 | Platelet Aggregati

4 | Smooth Muscle Cell Proliferation

Nitric Oxide (NO)- is an Endogenous (produced by cells inside the organism such as the Endothelium) Protector of the Vessel Wall. Nitric Oxide is produced by the Endothelium (inner wall of all your vessels) as a protector of the vessel walls. Nitric Oxide also is responsible to repair the problems of the vessels, which includes returning them to a supple state.

1 | Vasodilation

Nitric Oxide increases the area of the vessel and as such increases the flow of blood to the crucial organs.

2 | Platelet Aggregation

Nitric Oxide breaks up the aggregation (accumulation of blood platelets) and thereby keeps the vessel clean.

3 | Monocyte Adhesion

Nitric Oxide prevents monocyte adhesion. The monocyte is created in the bone marrow and enters the blood and migrates into connective tissue where it forms into a  acrophage to cause inflammation. Thus, inflammation pushes the blood vessels to get worse with time-nitric oxide blocks inflammation by inhibiting monocyte adhesion and thereby stops the progression.

4 | Smooth Muscle Cell Proliferation

Nitric Oxide blocks smooth muscle cell proliferation (growth). Proliferation of these cells makes the artery get narrower, so that less blood can flow to the organs. By reducing this mechanism, nitric oxide helps keep the arteries wide open.

5 | Superoxide Radical Elaboration

Nitric Oxide protects against this process of damage to the body. Superoxide radicals contribute to the development of many diseases and to the aging process because of oxidative stress, which damages cells and organ function.

6 | LDL Oxidation

Nitric Oxide reduces the oxidation of the bad cholesterol. Oxidation otherwise makes the bad cholesterol get even more aggressive in the blood vessels.

Asymmetric Dimethylarginine (ADMA)

Asymmetric Dimethylarginine

The science of the ADMA molecule & what the ADMA molecule can tell you:








Asymmetrical Dimethylarginine :

The Über Marker?  (ADMA)

John P. Cooke

Online Version | Click Here |


Download .PDF





These Health & Lifestyle Markers

Effect the Vascular System

1 | Smoking

2 | Cholesterol

3 | Diabetes

4 | High Blood Pressure

5 | High CRP (C-reactive protein)

Is used mainly as a marker of inflammation. Apart from liver failure, there are few known factors that interfere with CRP production.[2] Measuring and charting CRP values can prove useful in determining disease progress or the effectiveness of treatments.​

6 | LDL Oxidation

Nitric Oxide reduces the oxidation of the bad cholesterol. Oxidation otherwise makes the bad cholesterol get even more aggressive in the blood vessels.

The ADMA molecule is negatively affected by these 6 issues. Heart Disease and death follow if the ADMA is not attended to. The only real solution is an arginine/citrulline supplement. Your life style choices can change the ADMA in only a small amount.

ADMA is a Pro-Atherogenic Molecule

ADMA is a marker for cardiovascular disease. The study of 3600 patients over 20 years of the ADMA molecule established scientifically your likely life expectancy. If your ADMA is over 0.8 you will have a shorter life expectancy than those people who have a 0.5 level or lower (a much lower life expectancy). The most significant effect on this outcome is your production or supplementation of L-Arginine/L-Citrulline. You can have the blood test done to determine your ADMA, and we can do it for a cost of $149.99. If you currently have high blood pressure you will most likely have an ADMA of 0.8 or higher.