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Frequently Asked Questions

What can I expect after taking Arginine Advantage after the first 90 days?

1. After 10 years of selling an L-arginine/L-citrulline supplement we can say with confidence what you should experience in the first 90 days.

I - You will notice more energy because the vessels will expand for more blood flow. II-The L-taurine and CoQ10 (Ubiquinal) will feed more energy into your muscles. Your ability to exercise will increase and your stamina will increase. III - You should sleep better; avoid taking Arginine Advantage after 8:00pm. IV - You will not feel your vessels cleaning out. This takes about 2 years to complete. IV - If you have high blood pressure, do not expect it to work in the first 90 days. However, some people have a decrease in blood pressure in the first 90 days. Blood pressure is a function of many issues. They are: lifestyle, too little exercise, too much simple carbohydrates in your daily diet, Metabolic Syndrome (lose some weight), too much plaque buildup, and too brittle of arteries. Arginine Advantage cannot compete with all these issues at once. Over time you can reverse out the cardiovascular problems, but try to address some of these important lifestyle choices to help defeat cardiovascular disease. Blood pressure medications of any form are destructive to your body especially your heart and kidneys. Your goal should be to get off them completely, but you should consult your doctor before doing so. VI - Cut back on your salt intake. Salt causes the vessels to contract, and it also thickens your blood. These two issues can cause blood pressure to rise. High salt intake affects kidneys and causes cardiovascular disease. It also affects the function of the endothelium which produces Nitric Oxide. Consider the DASH diet.

2. Take the Arginine Advantage 2 times per day 10 - 12 hours apart. Take it on an empty stomach 1/2 hour before food or 2 hours after food, and drink it only with water - no smoothies or other food. It is best taken with 12 ounces of water for maximum effect and absorption. Some people like to take it with 2 to 4 ounces of water; and if you do, you will not get the best results. It will be less effective. If you cannot take it in this format, take it anyway, because it still works, but it might take longer.

3. In taking a full scoop you could experience some loose bowels to start with. Some people are sensitive to L-arginine. Please start out with 1/2 scoop once a day in the morning on an empty stomach. Then if all is well, after a couple of days take the second 1/2 scoop 12 hours later. Just keep working up as you tolerate the increase. You want to arrive at 2 scoops per day 10 to 12 hours apart on an empty stomach. If you discover after 60 days that your cardiovascular issues are not being resolved, take 3 scoops per day 8 hours apart. You might be arginine resistant and not absorbing it well. You also might have a high ADMA molecule. This a genetic issue, and you live with it all your life if you have it. This could mean you are very prone to cardiovascular and heart disease. One million people die from it every year in the USA, but Arginine Advantage can really affect this in a positive way. And it just might to the only way to affect it!

4. It is important to take Arginine Advantage 2 times per day 12 hours apart. Doing that will saturate the body with L-arginine and help your body build on itself ending up with 400% or 4 times as much nitric oxide production than you would have with only 1 scoop per day. This is very important. This doubling happens over 60 days.

5. Some people find that 3 scoops per day 8 hours apart is much more effective for them. That dosage is more than twice as effective as 2 times per day, especially if you are L-arginine resistant and have a high ADMA destructive molecule. The ADMA molecule is a genetic issue from your parents. Most people with cardiovascular disease have these conditions. ED and high blood pressure are both related to cardiovascular disease.

6. The ADMA testing would be very beneficial for you to understand the status of your genetic disposition for cardiovascular and heart disease. The test will tell if you are getting enough arginine into your system. The ADMA molecule determines your disposition for cardiovascular disease. The only thing to offset a high ADMA molecule is L-arginine correctly blended with L-citrulline. The Framingham study over 20 years tested 3600 people to determine the risk factors for a heart attack or stroke in the next 10 years of their life. This study also helped determine longevity based on the ADMA molecule.

7. The Nobel Prize for medicine was awarded in 1998 for research regarding L-arginine producing Nitric Oxide. Nitric Oxide reverses cardiovascular disease, both atherosclerosis and arteriosclerosis.

How soon can you stop taking Arginine Advantage?

Many of you might be thinking, "How soon can I get off ARGININE ADVANTAGE" Some even think that it should work like Drano!! Many think after 90 days they should see a major difference and that they should be able to get off it at that time. Dr. Siva Arunasalam, MD from the High Desert Heart Institute studied 30 patients (beyond medical treatment for cardiovascular disease) who were given an L-arginine supplement as treatment for cardiovascular disease. His statement to me regarding a customer who had been on L-arginine for one year and then had open heart surgery for four blocked arteries was, "It saved his life and will take about 2 to 5 years to complete the reversal of cardiovascular disease with L-arginine/L-citrulline supplement correctly formulated." You and many others have cardiovascular disease because of your ADMA molecule and your inability to make enough Nitric Oxide to offset the ADMA issue. What you should be thinking of is a lifetime of use.

If you decide to stop the Nitric Oxide build-up from the supplement Arginine Advantage that is happening in your blood vessel walls when using the product, you will allow the cardiovascular problem to return. With that in mind you will be more likely to stay out of the disease phase of life, live healthier and live much longer if you stay on the Arginine Advantage. It is a small price to pay for peace of mind concerning your future health.

Does L-Arginine Arginine Advantage work in all age groups?

L-Arginine is Effective in Elderly People Published by Dr. Rainer Böger Professor and Head, Clinical Pharmacology Unit Institute of Experimental and Clinical Pharmacology and Toxicology at the University Medical Center, Hamburg-Eppendorf - Author of more than 140 original research papers in peer-review journals (more than 60 papers on studies relating to ADMA and L-arginine supplementation).**

Recently, information is being spread through the internet stating that L-arginine is ineffective in old age, when restoring nitric oxide is most urgently needed the most. There is scientific proof that this statement is totally inaccurate.*** L-arginine is absorbed into the blood stream and converted into NO and only then and there - where it is needed by the body. L-arginine is converted into nitric oxide in the blood vessel wall - not in the blood itself. This happens even more strongly when combined at an optimized ratio with L-citrulline, as in Arginine Advantage*

The authors of this false information that L-arginine is ineffective in old age - notably Neogenis Labs give no reference to any scientific studies on which they base their statements. However, they claim that their product (**) is more effective in increasing nitric oxide in the body than any L-arginine product. They support this with a nice looking graphic for which they do not supply the source or publication. The graphic is supposed to show a higher increase in nitric oxide levels in blood generated from their product, which they claim to be a direct nitric oxide donor, than from L-arginine (actually, they show that L-arginine leads to almost no increase in nitric oxide at all).

Unfortunately, this information found on the internet is based on false assumptions; and, even more unfortunately, the ordinary arginine customer cannot distinguish where their claim is flawed. I wish to clarify the science behind nitric oxide and discuss the pros and cons of the different products and enable you to make your choice based on real, published, and reviewed science in a transparent manner. L-arginine/L-citrulline product, which is based upon real science, it can and will stand up against all false claims.** A. The graphic from Neogenis labs contains unpublished data that has never been critically reviewed by other scientists in the field. It shows the release of nitric oxide in a few milliliters of blood within a test tube. Of course, a direct NO donor does release NO into the blood under such artificial conditions. L-arginine does not, because L-arginine is converted into nitric oxide in the blood vessel wall - not in the blood itself.

B. When you swallow a direct NO donor such as a tablet from Neogenis Lab, it will release NO wherever it is. And it is... in the stomach after swallowing. High levels of NO in the intestinal tract causes diarrhea - if you consider that a desirable clinical effect, just go ahead! L-arginine does not cause trouble in the intestines, but it is absorbed into the blood stream and converted into NO only then and there - where it is needed by the body. This happens even more strongly when combined at an optimized ratio with L-citrulline, as in Arginine Advantage.**

C. The levels of nitric oxide as shown from Neogenis Labs in their graphic, if ever reached in a living human being, are detrimental to your health. Levels as such can only be reached in a living individual during septic shock - a life-threatening situation! So, it's good that this was an experiment in a test tube, because it has absolutely no meaning to your health!!

D. Is L-arginine ineffective in old age? Well, first of all, it is correct that in old age the biological action of nitric oxide is urgently needed. But, if the authors had known the scientific literature well enough, they should have known that as early as 2003, we published a placebo-controlled clinical study which explicitly addressed the effects of L-arginine on vascular function in individuals over 70 years of age: "Oral L-arginine improves endothelial function in healthy individuals older than 70 years." This scientific study was published in the journal Vascular Medicine after having been thoroughly reviewed by experts in the field. It showed that in 12 healthy older people (mean age, 74 years), as little as two weeks of L-arginine already caused a significant, measurable improvement of vascular function (i.e., improved flexibility of the arteries). L-arginine does work in older age people and stating it doesn't is a terrible falsehood.*** Arginine is the precursor of nitric oxide (NO), the major endogenous protector of the heart and blood vessels that the body can make. A sufficient supply of L-arginine is a prerequisite for the ability of our blood vessels to make NO. It is NO that keeps the blood vessels smooth and flexible. It is the decreasing ability of the arteries to make NO which leads to stiffening of the arteries, high blood pressure, and atherosclerosis.

My co-workers and I have published many more studies on the clinical effects of L-arginine. Amongst them is the discovery that the combination of L-arginine plus L-citrulline has superior effects on vascular health as compared to L-arginine alone. Arginine Advantage is the only nutritional supplement on the market that is based on this strong science!*** This is more than enough reason for you to use Arginine Advantage. No other dietary supplement is known to have such superior effect on cardiovascular health!

Be aware of false claims that you may be confronted with, especially in the internet, where many "experts" seed bits of information without providing the evidence for the correctness of their statements. Be wise and trust in the scientific data only!

Arginine Advantage is probably the greatest health supplement for your overall health.* The science for L-Arginine been proven in many experimental studies and clinical trials worldwide. I have many reasons to highly recommend this product to you, and I will continue to share more of the exciting data behind its unique formula with you in the near future. Our science for your health!

  1. * Results may very
  2. ** http://expertscape.com
    *** http://www.ncbi.nlm.nih.gov

What makes Arginine Advantage better than other l-arginine products?

Arginine Advantage has been formulated over 27 years by world famous researchers. There is a very important relationship between arginine and citrulline. The ratios must be exact to get 12 hours of nitric oxide production. Arginine Advantage has this correct ratio and with 2 scoops per day 12 hours apart you have the product working all 24 hours in the body. That amount of time is important for the customer to have early results on taking the product. All products on the market do not have this built-in ratio and it is proprietary. Almost all products have too much arginine and too little citrulline and therefore the arginine is just washed out with your waste water. Arginine by itself can only function for an hour or two.

After many experiments and early clinical studies had revealed that dietary L-citrulline causes an elevation of L-arginine blood levels. Our team conducted a clinical trial to show that a combination of L-arginine plus L-citrulline leads to a higher and more sustained elevation of Nitric Oxide in human blood than L-arginine alone.** After 12 hours - which is the relevant time point for twice daily intake - plasma L-arginine was still significantly elevated when combined L-arginine/L-citrulline was administered with the proper ratio of arginine/citrulline. Whereas L-arginine blood levels were completely back to baseline after administration of L-arginine within a short time frame with ratios of 4 to 1 or higher. All products on the market today have ratios from 5 to 1 up to 25 to 1. The amount of L-arginine/L-citrulline in the study was identical to the ratio in Arginine Advantage.

This is the important part of this study and why Arginine Advantage is more effective than any other product on the market. Once the ratio of L-arginine to L-citrulline is low enough the amount of Nitric Oxide production is double at the 6 week mark. In other words the amount of L-arginine going into your blood is double the amount in the daily dose. Most of the products that promote 1 scoop per day are very ineffective and ratios of 5 to 1 or higher are relatively ineffective at 2 scoops per day.* This is very important for your health and wellness.

How can I tell if it's working on me?

That is a very important question. If you have high blood pressure, recent heart attack, stents put in, or any one of a number of symptoms. L-arginine is known to produce Nitric Oxide and more Nitric Oxide has benefits. Every person is different because of their form of the disease and how far it has progressed. As a general rule, more Nitric Oxide works on reduction of blood pressure in the 1st 90 days. Cleaning out your 80,000 miles of vessels takes 2 to 4 years if you have sufficient Nitric Oxide levels.* The most difficult are the carotid arteries (in your neck going to the brain) and the arteries going into the heart. We don't know about calcified plaque - only soft plaque. The customer can have noticeable differences in the 1st year and sometimes tested differences in 3 months.* There are scientific results showing reductions of the most seriously clogged arteries both by increased flow and reduction of plaque when Nitric Oxide levels are high.***

How soon can I see results after starting Arginine Advantage?

Most people can see results in the 1st 90 days.* You will sleep better and you will have more energy. Most people will have some kind of reduction of blood pressure in the 1st 90 days.* You also will be able to process more oxygen into your blood stream and that allows you to walk more energetically.

If L-Arginine supplementation is so great, why aren't doctors prescribing it?

The Nobel Prize for medicine was awarded in 1998 concerning L-arginine as a signaling molecule for Nitric Oxide. That was 18 years ago. Research on L-arginine goes back to the 1980's. Yet today most doctors and especially internists do not prescribe it. Why? In medical school they do not teach about nutraceuticals. Medical schools' agendas are often driven by the pharmaceutical industry which do not have any interest in nutraceuticals because they cannot get patents or the high priced markups they need. Dr. Joseph Prendergast who was the first doctor to use arginine for his patients who had cardiovascular disease and/or diabetes (during 15 years and 20,000 patients) would send patients to three different cardiologists for procedures. After he had success with arginine supplementation which he carefully documented, he stopped sending his patients to them. All 3 cardiologists were concerned and came to see what they had done to offend him. His response was that he found a better way to help his patients.

There have been some studies that were negative about L-arginine; they were for the most part done with L-arginine as the only ingredient. The test results were inconclusive because they were flawed without citrulline as the titration agent to keep the arginine working longer than a few hours. Dr. Böger has published papers about the flawed L-arginine studies to show why they were flawed.**

Will this help my high blood pressure and can I stop taking my medication?

High blood pressure is a complicated medical condition. Each person is different and has different outcomes. For the most part everybody has some success and some have total success in normalizing their pressure when an increase in Nitric Oxide is constant.* Pressure is a function of their blood vessels' hardness and how clean you are. It is also a function of your body inflammation. This can be caused by poor diet, being overweight, not enough sleep, no exercise and stress. All these play into body inflammation. More Nitric Oxide may help reverse hardness of the blood vessels making them more flexible and helping the body fight inflammation.*

After you see results with ARGININE ADVANTAGE® and your blood pressure drops you may be able to reduce meds with Doctor’s permission.

Will Arginine Advantage build Nitric Oxide?

Arginine Advantage helps the body produce Nitric Oxide. If the arteries are brittle, they will not flex when the heart pumps and that causes pressure. If the vessel is compromised with plaque, that will restrict the flow and cause pressure. What happens is the Nitric Oxide repairs the endothelium first. (The endothelium is an organ inside the blood vessel and its job is to make Nitric Oxide from L-arginine in the blood stream). When the repair is complete then the system can make Nitric Oxide normally. When that happens the system stops the production of plaque and also starts reducing it over time. As the plaque reverses, the Nitric Oxide starts to reverse the hard vessel and makes them supple again. Dr. Böger has done those studies and they are found here:


Will Arginine Advantage help with diabetes?

Arginine Advantage cannot cure diabetes, but more Nitric Oxide can help with many the problems associated with it. Many people experience reducing or eliminating Metformin (a pharmaceutical often prescribed for Type II diabetes) and some have reduced insulin as well. Diabetes ravages all the organs of the body and more Nitric Oxide production helps

Can Arginine Advantage help with kidney disease?

Arginine Advantage, because of the L-arginine and high amounts of anti-oxidants, can repair and clean the kidneys of the plaque problem.* Dr. Joseph Prendergast has had huge success with this combination of nutraceuticals. He sometimes held patients off kidney transplants and dialysis to try this treatment first.

Can Arginine Advantage help with arthritis?

Arthritis pain comes from inflammation and poor circulation. Both these conditions are helped immensely with an increase in Nitric Oxide production.*

How long must I take Arginine Advantage for my Nitric Oxide deficiencies?

Most people who have it received an atherosclerotic gene from their parents produce less Nitric Oxide. What this means is the person is aging much faster than normal within their cardiovascular system and heart. With that problem and non-production of Nitric Oxide, the person will die substantially earlier than normal, usually 20 years earlier. Also there are lots of problems with health along the way - stents, high blood pressure, high cholesterol, high triglycerides, diabetes, strokes, and heart attacks. One million people die every year in the USA of heart disease. That is like 3 jumbo jets crashing without survivors every day. Therefore, it is wise to consider taking the product for the rest of your life if you have this deficiency.*

Can Arginine Advantage solve my neuropathy?

Neuropathy is a condition where the extremities, hands, feet and legs have less feeling in them than normal. This condition is made up of two problems. (1st) The blood vessels in the extremities have been compromised. (2nd) The nerve endings have been damaged. Nitric Oxide helps the blood flow to these areas as we age. If their problem is nerve endings, that repair takes longer and is usually not 100%. If the problem is one or both, there is some relief after a few months by increasing Nitric Oxide levels.*

What are the long term benefits of arginine supplementation?

The long term benefits are better health and a longer life and there are no known long-term side effects of arginine at the doses we recommend. Dr. Rainer Böger MD and Dr. John Cooke PhD, MD have devised a blood test to evaluate the health of your cardiovascular system and your level of arginine production. The study has been evaluated over 20+ years with 3500 people. What the study concluded was that 85% of the adult population will fail the test. That is their cardiovascular system will be compromised in their lifetime and reduce their life span. What that means is 85 people out of 100 need of more Nitric Oxide to have a long healthy life span. The test can be administered for $150.00 and it is called the ADMA molecule test. Request a ADMA test kit on our contact form page | CLICK HERE | or by calling us at (888) 270-3666

What do I say to my doctor about Arginine Advantage? I have an appointment soon . . .

You just have to ask what they know about L-arginine and Nitric Oxide. The doctor will most likely be uninformed. Dr. Louis Ignarro, PhD, head of Pharmacology at UCLA, who was one of the 3 Laureates in 1998 who was awarded the Nobel Prize for medicine, wrote a book on Nitric Oxide and cardiovascular disease. The book is called NO More Heart Disease (the NO stands for Nitric Oxide). It will almost be certain your doctor knows very little about the book or L-arginine. However, I have had people buy the book and put it on the table while they discuss the issue of taking L-arginine.

I know someone who had open heart surgery after 1 year of taking Proargi9 or some other arginine supplement. Why did it not work for them?

Most products usually cannot work fast enough for blockages next to the heart. We do not know if Arginine Advantage can either. No product in the world works for everybody's therapy; that means that there are always some individuals who do not show a good response to the treatment because of their state of the disease. One year is too short; it may take 2 years or more depending on how occluded the arteries are for Nitric Oxide to work inside the body. Also how much did they take each day and how spaced out was their therapy dose? There are usually a lot of unknowns and the patient may be unaware of exactly what his condition was before he started supplementing.

The root cause of almost all disease is inflammation. Does Arginine Advantage address that problem?

Resveratrol, Curcumin, and Vitamin D3 work synergistically to reduce inflammation. They are the three strongest forms of inflammation control and Arginine Advantage has these ingredients.*

Can Arginine Advantage help with dementia?

Dr. Böger has in one of his 100 published papers evidence that L-arginine goes across the blood brain barrier and may helps the system in the frontal lobe where processing for memory is located.** Also curcumin goes across the same barrier and may help clean out the free radical rust in the brain.* Together they are a dynamic duo in brain dementia health.*

What is the difference between taking a pharmaceutical drug and Arginine Advantage?

Pharmaceuticals are designed for maintenance not for cures of diseases. Also nutraceuticals are not supposed to be touted as a cure for any disease. So be careful. They may be cures, but we cannot say they are. The science may be telling us that cures are happening, but we cannot make that claim, that was the deal with the FDA years ago to avoid regulation. However a research doctor can make the claim based on his own research work.

The pharmaceutical industry is slowly coming around concerning health versus maintenance. The future is wellness and better health, and that is what Arginine Advantage is bringing to the table. Niger Jones, head of Healthcare Sector of England stated in the Financial Times on 1/27/14, that Big Pharma must change its approach to health and wellness. This idea that they can just make a profit off maintenance is outdated and out of vogue. Arginine Advantage has been brought to market with health and wellness as a goal and with 27 years of scientific study by Dr. Rainer Böger MD.

I'm satisfied with my current product, why would I want to change?

The biggest reason is effectiveness and cost. All products on the market, according to their daily dose, only function a few hours per day or less. You are satisfied because you may not know what is really happening inside. Your cost is considerably more than Arginine Advantage to have the same effectiveness. Also your product has never been scientifically studied. If you think so, tell me who the doctor is? Where are his published papers? There is only one other product that has a major doctor behind it and that is Niteworks sold by Herbalife. That doctor is Dr. Louis Ignarro and the product sells for $90 for 1 scoop per day for 30 days. I don't know of one other arginine product that been studied except for Arginine Advantage and I know all the leading products. Why not have the best for less?

What do you think of Nitric Oxide pills and the strips to test for Nitric Oxide? Do they work?

There are products being promoted as better than arginine as a cardiovascular solution. They claim that Nitric Oxide must be produced in the mouth, not in the stomach or intestines. The truth is Nitric Oxide must be produced in the tissues, arteries, in the heart, in the brain and in the bones. Nitric oxide that is produced in the mouth will be swallowed and the gastric acids will convert it into nitrite and nitrate, where both are inactive. Arginine goes into the stomach, then in the blood and the endothelium in the vessels, and produces Nitric Oxide.

These companies say they measure Nitric Oxide in saliva. That is a great marketing tool when you sell a product that increases Nitric Oxide generation in the mouth. The only thing worth testing is what is in the blood according to Dr. Rainer Böger.